Tadalafil in the treatment of lower urinary tract symptoms and erectile dysfunction
نویسندگان
چکیده
10.2217/14750708.5.3.355 © 2 In the aging male, erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common conditions that have been shown to be related. As life expectancy increases, treatments that target both ED and LUTS will prove increasingly valuable over the coming years. Phosphodiesterase type 5 (PDE5) inhibitors are used primarily to treat ED. Recently, studies have shown that improvements in LUTS are also seen with PDE5 inhibitor treatment. In particular, the PDE5 inhibitor tadalafil may be beneficial owing to its unique long-acting pharmacokinetic properties. We review the current literature to provide an insight into how tadalafil could provide symptomatic relief from ED and LUTS.
منابع مشابه
Efficacy and safety of tadalafil monotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a meta-analysis.
OBJECTIVE To evaluate the efficacy and safety of tadalafil monotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). METHODS A comprehensive search was done to identify randomized controlled trials comparing the efficacy and safety of tadalafil for LUTS/BPH with placebos. Meta-analytical techniques were applied to evaluate the differences in the study ...
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Lower urinary tract symptoms (LUTS) and erectile dysfunction increase with age. Several studies have identified a true association between these two disorders. Basic research studies have shown a significant decrease in the nitric oxide/cyclic guanosine monophosphate pathway with age that leads to decreased relaxation of the bladder wall and prostate and worsening LUTS. In this review article, ...
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Previous Conclusions and Recommendation: Evidence does not support a difference in efficacy/effectiveness Evidence does not support a difference in harms/adverse events Tadalfil demonstrated improvements in urinary symptoms compared to placebo in patients with lower urinary tract symptoms, but demonstrated no difference in post void residual volume or urinary flow rate. Tadalafil is als...
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